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In these conditions, although total serum vitamin B12 concen­trations may appear elevated or apparently normal, tissue vitamin B12 concen­trations will be low (Arendt & Nexo, 2012)

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Among these conditions, MSKs, including a wide range of inflammatory and degenerative diseases such as osteoporosis, osteoarthritis (OA), rheumatoid arthritis (RA), and sports injuries, are some of the most common causes of chronic disability worldwide ( In recent years, neurological, cardiovascular, and neoplastic diseases have been the focus of both ferroptosis research and clinical applications ( Mechanisms and regulation of ferroptosis The mechanism of ferroptosis has been summarized almost perfectly ( Iron metabolism All these observations allowed the identification of iron as a critical cofactor in various biochemical enzyme-catalyzed reactions involved in the physiological regulation of oxygen transport, energy metabolism, DNA synthesis, and repair