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2 S-nitrosylation: a stable alternative for NO• signaling regulation under inflammatory and oxidative stress NO• is a gaseous free radical synthesized endogenously by three distinct nitric oxide synthase (NOS) isoforms: neuronal NOS (nNOS or NOS1), endothelial NOS (eNOS or NOS3), and inducible NOS (iNOS or NOS2) (9) ( Figure 1A )
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