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Dihexa (also known as PNB-0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the blood–brain barrier and has shown synaptogenic effects in preclinical models. The often-quoted

Studies in rats for injury have looked at 10ng/kg up to 10mcg/kg both orally and via injection.6 The human equivalent dose of 10mcg/kg in rats per FDA provided calculations would be 1.89mcg/kg, corresponding to approximately 110 – 130mcg doses in a 60 to 70kg human.7 Though appropriate dosing for humans remains unclear given the lack of studies, animal data suggests a very favorable safety profile, with studies unable to report the acute lethal or toxic dose via the intramuscular, intraperitoneal, intravenous, or oral routes in animal trials in rats or dogs looking at dosing from 6mcg/kg all the way up to 20mg/kg over a 6 week period.5 BPC-157 has also been studied in a limited capacity topically in animals, with one study on burn wounds evaluating the effect of BPC-157 in a cream at 1mcg/g

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[57] found refractive error in a 22-year-old Australian female patient with SLE who suffered from blurred vision and periorbital edema was -7.50 DS in the right eye and -3.50 DS in the left eye, with periorbital edema and conjunctival edema in both eyes [58]