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Published mouse studies using oral and IP administration of NNMT inhibitors demonstrate significant reductions in body weight, fat mass, and plasma lipids in diet-induced obesity models, establishing oral bioavailability as a feature of this compound class

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indicated that the peptide reduced over 50% of body weight gain in these laboratory models compared to controls, with heightened lipolytic activity observed within the adipose tissues of exposed rats, alongside an absence of notable disruptions in insulin sensitivity in these experimental settings