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Glucose oxidase (GOx) is a natural enzyme that binds glucose and catalyzes its conversion to gluconic acid and hydrogen peroxide (H 2 O 2 ), and is therefore considered a candidate for regulating the high-glucose microenvironment in diabetic wounds

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For example, the deletion of compo-nents of the glutathione detoxication system such as glutathione peroxidase (Mirochnitchenko et al ., 1999) and glutathione transferase-pi (GST-pi) (Henderson et al ., 2000) both afforded partial protection against paracetamol hepatotoxicity