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Resting heart rate remains a titration marker rather than a one-time measurement.¹⁴ How to Titrate, and the Cost of Going Too Fast The final dose shapes the endpoint, but the length of escalation and the number of steps are the largest measured regimen-level drivers of tolerance

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On day 14, there is still an infiltration of inflammatory cells in controls, presented moderate edema which disappears not before the day 28 (Figure 9), sustainable, but delayed discrete increase of vascularity with the discrete proliferation of fibroblast and production of reticulin and collagen fibers making loose connective tissue with mesh-like fibers, areolar tissue