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Biosynthesis and phylogenetic distribution A particular feature of ERG is that although it is more or less universally distributed among higher organisms, none of them – as is consistent with the idea that it may in fact be a vitamin requiring exogeneous sources – can in fact biosynthesise it
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Subsequent cell-based work has documented elevated intracellular NAD+ and increased sirtuin pathway activity following NNMT inhibition in adipocyte cultures
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