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Patients with sufficient vitamin D had lower MMP1 and MMP13 levels compared to those with insufficiency of vitamin D, suggesting that vitamin D promotes anti-resorption by upregulating antioxidant enzymes like PON-1 and TAC and downregulating MMPs like MMP1 and MMP13, to protect against cartilage degradation in OA
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[88] reached the same conclusion and analysed pregnancy supplementation with antioxidants (selenium, vitamin C, vitamin E, lycopene, and multivitamins)
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