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Peripheral blood mononuclear cells (PBMCs) are a diverse group of immune cells including lymphocytes (T cells, B cells, and NK cells) and monocytes, that play a role in immune function and inflammation

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At the structural level, we could do a protein structure alignment of the wild and mutant versions of the enzyme with and without ligands (enzyme cofactor and substrates) to know the exact interaction and how this mutation affects both the structure and activity of the enzyme