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In an OIS model induced by Nras G12v overexpression in hepatocytes of immunodeficient Nod Scid Gamma (NSG) mice, senescent cells were successfully eliminated when treated with the anti-uPAR CAR-T cells
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The latter, called sirtuins, are known to regulate important physiologic functions, such as metabolism, cell cycle, genome maintenance, and aging processes 4,5,6,7,8
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