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Guggulsterone Selectively Modulates STAT-3, mTOR, and PPAR-Gamma Signaling in a Methylmercury-Exposed Experimental Neurotoxicity: Evidence from CSF, Blood Plasma, and Brain Samples | Molecular Neurobiology | Springer Nature Link

Monitoring and Adverse Effects Plasma creatinine, alanine, and aspartate transaminases monitored at 2-, 4-, 8-, 12-, and 16-weeks (Figure 1B) did not show any increase compared to baseline values (Table 4)

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In immunosenescent mice, although not showing any statistical difference, the administration of VitE increased the ratio of naïve to effector-memory T cells, suggesting that VitE may be effective in restoring oxidative stress-induced immunosenescence (101)