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For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

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For enrichment analysis, isotopically labeled glucose ( 13 C 6 glucose), acetate ( 13 C 2 acetate), or palmitate ( 13 C 16 palmitate) was added to culture media and the enrichment into acyl-CoAs was determined using FluxFix based on samples treated with no isotope tracer 48