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In addition, a broader set of metabolites were downregulated during this time course, including cytidine, L-threonine, S-adenosylmethioninamine, adenosine, folate, D-glucose 6-phosphate, sedoheptulose 7-phosphate, succinic acid, L-lysine, citrulline, S-adenosyl-L-methionine, AMP, glutathione, ornithine, UDP-glucuronate, UMP, L-arginine, kynurenate, glucosamine 6-phosphate, methylglyoxal, xanthine, acetic acid, N1-acetylspermine, and acetoacetic acid

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Its complete function remains elusive, and fluctuations in PRH can influence hormone equilibrium and reproductive life span