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Examples of other classes of therapeutic agents suitable for use in the combinations and methods herein include antivirals such as ribavirin, anti-fungal agents such as amphotericin, intraconazol and voriconazol, anti-rejection drugs such as cyclosporine, tacrolimus and sirolimus, bronchodilators including but not limited to anticholinergic agents such as atrovent, siRNAs, gene therapy vectors, aptamers, endothelin-receptor antagonists, alpha-1-antitrypsin and prostacyclins

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Overall, COMT inhibitors and MAO‐B inhibitors are used in combination with levodopa to prolong its effects and reduce fluctuations, and dopamine agonists can delay the need for levodopa in early disease stages and reduce dyskinesia risk—though they may cause impulse control disorders and hallucinations as side effects [6, 9, 10]