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Remarkably, 3-PHP (its canonical substrate) and GLU-derived α-KG share structural similarities, enabling overexpressed PHGDH to aberrantly reduce α-KG (using NADH) to D -2HG and NAD + , rather than processing 3-PHP to 3-PG
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By using biocompatible lipids, liposomes protect the glutathione and allow it to be transported through the lymphatic system, which also avoids the first-pass hepatic metabolism of the glutathione
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