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It is also expected that younger patients may tolerate busulfan myeloablation much better than older patients with organ dysfunctions related to iron overload, although the issue of fertility cryopreservation needs to be discussed with individual families as part of the consent process (as infertility is a common long-term toxicity of busulfan and sperm or egg cryopreservation options may be limited in younger patients compared to adults)
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