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However, it should be pointed out that the methods used to determine “mitochondrial ferroptosis” in existing studies are relatively scattered, involving membrane potential, ROS, ultrastructural changes, among others, many of which are not specific to ferroptosis

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38 Furthermore, disturbances in amino acid metabolism, particularly involving glutamine, arginine, and proline, suggest an imbalance in protein turnover and collagen remodeling, processes critical for maintaining cartilage integrity

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