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Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer’s disease

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The kinetic constants (K M and V max ) were obtained according to Michaelis–Menten equation: V = V max [S]/(K M + [S]) (1), where V was the initial velocity, [S] was the concentration of the substrate, K M was the Michaelis−Menten constant, and V max was the maximal reaction velocity