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First, ferritin can reprogram the immune microenvironment of tumors, and similar mechanisms may also be operative in the AML-supporting bone marrow microenvironment where various immunocompetent cells (including macrophage subsets) seem to support the leukemic cells [53,54,68,71,72,73,125]
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Boosters are additional doses of the same vaccine needed to maintain immunity if it decreases over time
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