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In this order of ideas, it seems plausible that in the high-DHA diet, lipid-derived hydroperoxides must be elevated in the more prooxidant environment of brain parenchyma in transgenic animals, including DHA-related HHE, which may trigger the stimulation of Nrf2 transcription factor, which eventually would favor the activation of a transcriptional program to increase Gpx4 isoforms expression, especially the cytoplasmic isoform

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doi: 10.1038/s41579-019-0287-1 139 ZhangT.GaoG.KwokL.SunZ

providing support for endurance exercise (aerobic) and during recovery from high intensity activities such as weightlifting and sprinting (anaerobic)