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The inflammatory cellular infiltration, such as neutrophils and macrophages, mediating prolonged airway inflammation can be induced, and inflammatory cytokines are released, such as TNF-α as an initial proinflammatory cytokine stimulating the expression of downstream cytokines, such as IL-1β(6)
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This effect is attributed to the upregulation of hepatic β-catenin, which helps to restore the integrity of tight junctions and normalize the expression of bile transport proteins (OATP2, BSEP, and NTCP1), ultimately inhibiting intrahepatic bile duct dilation, cholestasis, and the progression of fibrosis
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