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In hepatitis B Virus (HBV)-related hepatocellular carcinoma (HCC), hepatitis B protein X (HBx) induces aerobic glycolysis and produces a large amount of lactic acid through NF-κB/hexokinase 2 (HK2) signaling, which further activates PI3K/AKT signaling and improves the malignant proliferation ability of HCC cells
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