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An exception was China, which, while being strikingly devoid of the Human-SFB-refML lineage, with a dataset of 21 separate projects and 205 SFB-positive samples, showed a clear mixed sample population of Human-SFB-refChicken and Human-SFB-refMouse at 32.7% and 59.5%, respectively, with 76% of bioprojects displaying a mixed SFB lineage designation (Fig

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Under these conditions, this imbalance leads to intense competition for available chaperones, impairing their ability to assist in the folding of other substrates, including newly synthesized and damaged proteins