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This finding is consistent with the results of other studies that have shown that vitamin B12 plays a significant role in protecting and maintaining the stability of the human genome against mutagenicity induction by some genotoxic drugs such as ribavirin (Joksic et al., 2006), pioglitazone (Alzoubi et al., 2012), Paclitaxel (Alzoubi et al., 2014), thimerosal (Waly et al., 2016), and in hemodialysis patients (Stopper et al., 2008)