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This pathway is regulated by two key enzymes, CBS and CSE, furthermore, these two enzymes can also use cysteine as a substrate and are dependent on pyridoxal-5’-phosphate to produce dihydrogen sulfide as shown in the Figure 1
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Moreover, a large body of literature exists on the bidirectional relationship between CKD and the circadian clock system, where CKD causes multiorgan or whole-body chronodisruption and the dysfunction of the circadian clock or perturbation of circadian rhythms aggravate CKD and its complications (4)
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