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In humans, they appear to have the same effect on cancer cells, as they inhibit certain stages of carcinogenesis and induce apoptosis of numerous cell lines [123]
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Immunization with heterologous type II collagen in complete Freund’s adjuvant (CFA) to genetically susceptible mice strains with MHC haplotypes H-2 q or H-2 r (DBA/1, B10.Q, and B10.RIII) leads to the generation of autoantibodies against self-antigens and collagen [200]
ageing causes a decline in the production of cell energy
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