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To increase the entropy of water following exposure of HNE-bound hydrophobic regions of the proteins (14), other exposed hydrophobic regions of the same or different proteins will interact, i.e., this leads to protein aggregation of similar or different HNE-bound proteins (15)
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The SM-HLCs have significantly enriched glycerin, serine and threonine metabolism and have increased TCA cycle intermediates and lactate dehydrogenase-1 (LDH1) expression (Figure 5)
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