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It has been observed that soluble factors, such as IL-10 and/or transforming growth factor beta (TGF-β), or cell–cell contact are mainly involved in the suppressive activity of Treg cells ( The Influence of Cytokines, Chemokines, and TFs on CD8+ T Cells The fate of CTLs can be influenced by numerous inflammatory cytokines, TFs, and chemokines
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9 The second mechanism, neurogenic inflammation, or inflammatory responses triggered by neuronal activity, results in the circulation of inflammatory regulators that exacerbate migraine-related pathology
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