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doi:10.1016/j.nut.2021.111231 Park S, Kang S
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10 Mitochondria play a crucial role in initiating PANoptosis 10.1 Mitochondrial dynamics imbalance and reduced membrane integrity trigger PANoptosis AβO has an affinity for membranes, forming ion channels on the membrane surface, resulting in a large influx of Ca 2+ into mitochondria and leading to VDAC oligomerization, mPTP opening, and inner mitochondrial membrane permeability to solutes as large as 1.5 kDa (Norenberg and Rao, 2007)
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