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NAC inhibits NF-κB activation and upregulates nuclear factor erythroid 2-related factor 2 (Nrf2), promoting cellular antioxidant defences (Table 4) (Chen et al., 2025)
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The integration of these pharmacological and nonpharmacological approaches is crucial in addressing the multifaceted nature of fibromyalgia, highlighting the need for personalized treatment plans that consider individual symptoms, preferences, and tolerances
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