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Figure 2 3.1 Regulating peripheral CD4 + T cell differentiation via epigenetic regulation As a metabolite of intracellular glutaminolysis, α-KG not only participates in the TCA cycle and the generation of other amino acids, but also participates in the regulation of histone and DNA methylation levels as a cofactor of peroxidase, thus participating in the regulation of gene expression in cells ( + T cells even inhibited the expression of Foxp3 under the condition of Treg cells ( + T cells into Th1 cells and increases the generation of Foxp3 + Treg cells, and this effect can be reversed by the α-KG analogue ( + T cells led to the reduced expression of PIK3IP1,a negative regulator of mTORC1, further leading to the activation of mTORC1 to promote the differentiation of effector Th1 cells (35)

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