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Notably, LPS-CD14 binding via pattern recognition receptors not only mediates innate immune activation but has been mechanistically linked to insulin resistance, obesity, and DM pathogenesis (Cani et al., 2007)
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p53 can induce ferroptosis by suppressing the expression of the SLC7A11 subunit in the Xc - system and enhancing the expression of spermidine/spermine N1 - acetyltransferase 1 (SAT1) and glutaminase 2 (GLS2) [74–76]
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