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Recognizing the crucial role of elevated LRRK2 kinase activity in PD pathogenesis, multiple research groups have undertaken studies to quantitatively assess LRRK2-related phosphorylation across various tissues and biofluids, exploring their potential of being used as a PD diagnosis (Wang et al., 2017
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Depletion of CREB activity in pancreatic β-cells leads to hyperglycemia due in part to diminished expression of IRS-2, excessive β-cell apoptosis and decreases in insulin secretion (Withers et al., 1998
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