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470 The ent -16( R , S )-13- epi -ST-Δ 14 -9-PhytoF 83 , ent -16( R , S )-9- epi -ST-Δ 14 -10-PhytoF 84 and ent -9( R , S )-12- epi -ST-Δ 10 -13-PhytoF 85 were made in 20 steps from the commercially available but-2-yne-1,4-diol 80 , via a Payne rearrangement of the bis -epoxide intermediate 81 , which yielded the tetraol THF intermediate 82 (Scheme 80)
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For example, in glioma cells, overexpression of Nrf2 or knockdown of Keap1 accelerates proliferation and confers resistance to ferroptosis (146)
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